Audio Case Report, September 2014

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Select the best answer to each question. All fields are required.
1 The majority of studies have shown an association between_____and poor prognostic features of PCa, specifically high-grade disease, advanced pathologic stage, and increased risk of biochemical recurrence following radical prostatectomy.
 low serum testosterone
 high serum testosterone
 insulin resistance
 low body mass index
2 Clinicians should weigh the risks and benefits a testosterone therapy which may include improved _____.
 bone-mineral density
 mood and energy
 sexual function that may positively affect intimacy and relationship
 all of the above
3 The Saturation Model suggests that ______.
 the relationship of testosterone to prostate cancer growth is that of "fuel for a fire"
 prostate cancer growth is exquisitely sensitive to variations in androgen levels at very low concentrations but becomes insensitive to such variations at high concentrations
 prostate cancer growth is exquisitely sensitive to variations in androgen levels at very high concentrations but becomes insensitive to such variations at low concentrations
 prostate cancer growth is exquisitely sensitive to variations in androgen levels at any concentration
4 Which of the following statements is true:
 Early data suggest minimal risk of cancer recurrence or progression in properly selected men with a prior history of PCa treated with testosterone therapy
 Multiple reports of testosterone therapy in men after treatment for localized PCa have shown low or absent recurrence rates
 Some men with untreated PCa have received testosterone therapy without evidence for PCa progression
 All of the above
5 Which of the following criteria should be considered when evaluating the appropriateness of prescribing testosterone therapy for patients with documented hypogonadism, after radical prostatectomy?
 Patient must understand that safety data are limited and that there is a degree of risk of PCa progression or recurrence, as part of informed consent
 Clinician must ensure that there are no medical contraindications to testosterone therapy and ensure PSA level is undetectable or stable
 Clinicians must be prepared for the possibility of PCa recurrence or progression, which will occur in some men regardless of testosterone therapy but may be attributed to testosterone therapy by patients, family, or other clinicians
 Testosterone therapy should be used with extreme caution in men at high risk for PCa recurrence or progression; testosterone therapy is not recommended for men currently receiving any form of ADT
 All of the above
© 2014 CogniMed Inc. All rights reserved.                           TU16001                           September 2014